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Tenovin-6 1011557-82-6

Product Description

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Molecular Weight:

454.63 Tenovin-6 is a small molecule activator of p53 transcriptional activity.


Biological Activity


Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts
through inhibition of the protein-deacetylating activities of SirT1 and
SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified
human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and
67 μM, respectively.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)










Chemical Information




Molecular Weight (MW) 454.63
Formula

C25H34N4O2S

CAS No. 1011557-82-6

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms N/A



Solubility (25°C) * In vitro DMSO 98 mg/mL (215.55 mM)
Water 98 mg/mL heating (215.55 mM)
Ethanol <1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.




Chemical Name Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-







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Product Categories : Apoptosis > p53 Inhibitor