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Home > Products > Metabolism > PDE Inhibitor > Doxofylline 69975-86-6

Doxofylline 69975-86-6

Product Description

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Molecular Weight:

266.25 Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.






Biological Activity


Doxofylline has PDE Inhibitor activity and can increase the level of
cAMP, which could, therefore, be used for the treatment of asthma and
COPD. EC50 value of Doxofylline is 15 times higher than that of
aminophylline in inhibiting the adenosine-induced relaxation of
tracheal smooth muscle and 10 times higher in reducing the negative
inotropic effect induced by adenosine on isolated guinea-pig atria.


Doxofylline could effectively decrease the open probability of the
calcium-activated potassium channels as a result of both the shortening
of open period and the prolongation of close time. Doxofylline has
greatly decreased affinity towards adenosine A1 and A2 receptors when
compared with theophylline, which may contribute to the better safety
profile. Moreover, unlike theophylline, Doxofylline does not interfere
with calcium influx into cells nor antagonizes the action of
calcium-channel blockers.


Doxofylline has been shown to have better efficacy with fewer side
effects than theophylline. 30 mg/kg Doxofylline increases heart rate of
anaesthetized cat by 13 beats/min. The effective therapeutic dose of
Doxofylline has less cardio-stimulant effects than Theophylline, such
that Doxofylline does not out significantly increase the cardiac
frequency nor does it have arrhythmogenic effects.





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