Tadalafil 171596-29-5

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Molecular Weight:

389.4 Tadalafil is a PDE-5 Inhibitor with IC50 of 1.8 nM.






Biological Activity


Tadalafil binds to PDE5 with KD of 2.4 nM. cGMP stimulates the binding of [3H]Tadalafil. Tadalafil (1 mM) results increased CYP3A protein expression in human hepatocytes.


Tadalafil (2 mg/kg) almost completely restores penile oxygenation and
abolishes neurotomy induced increase and substantially rescues
muscle/fiber ratio in penile sectionsin sham-operated rats.


Tadalafil (2 mg/kg or 10 mg/kg) significantly improves neurological
functional recovery and increases cerebral vascular density and the
percentage of BrdU-positive endothelial cells around the ischemic
boundary.


Tadalafil selectively increases cGMP but not cAMP in brain of
rats. Tadalafil decreases the number of apoptotic cells
and increases the phosphorylation of the 2 survival associated kinases
Akt and extracellular signal-regulated kinase 1/2 in mice.

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Product Categories : Metabolism > PDE Inhibitor