862.74 Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Sennoside B, a kind of irritant laxative isolated from rhei rhizome,
inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell
proliferation by binding to PDGF-BB and its receptor and down-regulating
the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with
sennoside B inhibits the phosphorylation of pathway components including
Ak strain transforming protein (AKT), signal transducer and activator
of transcription 5 (STAT-5) and extracellular signal-regulated kinase
1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.
LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
|Body Surface Area (m2)||0.6||0.5||0.24||0.15||0.05||0.025||0.02||0.007|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×||mouse Km(3)||= 11.2 mg/kg|
|Molecular Weight (MW)||862.74|
|Storage||3 years -20℃Powder|
|6 months-80℃in solvent (DMSO, water, etc.)|
|Chemical Name||[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-|
Molecular Weight Calculator
Tech Support & FAQs
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