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Product Description

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Molecular Weight:

862.74 Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.


Biological Activity


Sennoside B, a kind of irritant laxative isolated from rhei rhizome,
inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell
proliferation by binding to PDGF-BB and its receptor and down-regulating
the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with
sennoside B inhibits the phosphorylation of pathway components including
Ak strain transforming protein (AKT), signal transducer and activator
of transcription 5 (STAT-5) and extracellular signal-regulated kinase
1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.


LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)






Chemical Information




Molecular Weight (MW) 862.74
Formula

C42H38O20

CAS No. 128-57-4

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms






Chemical Name [9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-







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Tech Support & FAQs




Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Inhibitors, and issues that need special attention for cell-based assays and animal experiments.


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Product Categories : Protein Tyrosine Kinase > PDGFR Inhibitor

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