API/Pharmaceutical Grade Ticagrelor 274693-27-5 GMP ISO
Basic Info
Model No.: YH-P-2
Product Description
Factory supply high quality Drug Ticagrelor with cas.274693-27-5 in stock
Ticagrelor (trade name Brilinta, Brilique, and Possia) is a platelet aggregation inhibitor produced by AstraZeneca.
Ticagrelor is an antagonist of the P2Y12 receptor.
Ticagrelor is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 2010.The drug was approved by the US Food and Drug Administration on July 20, 2011.
Ticagrelor is an antagonist of the P2Y12 receptor.
CAS No: 274693-27-5
Synonyms: Ticagrelor;AR-C126532;AZD6140; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-
5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol; AR-C 126532XX
Molecular Formular: C23H28F2N6O4S
Molecula Weight: 522.568
Appearance: White or whitish crystalline powder
Uses: pharmaceutical
2. Chemical Specification
Identification: IR
HPLC
Loss on drying: ≤0.5%
MP ref.: About 146~152 c degree
Optical rotation: Methanl C=1
Residue on Ignition: ≤0.5%
Related substance: Single impurity: ≤0.5%
Total impurities: ≤1.0%
Assay(HPLC): ≥99.0%
Assay by titration: 99~101%
3. Medical uses
Ticagrelor is used for the prevention of thrombotic events (for example stroke or heart attack) in people with acute coronary syndrome or myocardial infarction with ST elevation. The drug is combined with acetylsalicylic acid unless the latter is contraindicated.
There is no high quality evidence for the use of ticagrelor in non-ST elevation acute coronary syndrome.
The FDA indication for tigagrelor is reduction of the rate of cardiovascular death, myocardial infarction (MI), and stroke in people with acute coronary syndrome or history of myocardial infarction.
AHA/ACC Guidelines (09/2014) state: "It is reasonable to choose ticagrelor over clopidogrel for P2Y12 inhibition treatment in patients with NSTE-ACS treated with early invasive strategy and/or coronary stenting".
4. Contraindications
Contraindications for ticagrelor are: active pathological bleeding and a history of intracranial bleeding, as well as reduced liver function and combination with drugs that strongly influence activity of the liver enzyme CYP3A4, because the drug is metabolized via CYP3A4 and excreted via the liver.
| Ticagrelor | |||
| Chemical Data | CAS No | 274693-27-5 | |
| Synonyms | Ticagrelor;AR-C126532;AZD6140; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]- 5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol; AR-C 126532XX | ||
| Molecular Formular | C23H28F2N6O4S | ||
| Molecula Weight | 522.568 | ||
| EINECS NO | NO | ||
| Appearance | White or whitish crystalline powder | ||
| Packing | 25kg fibre drum | ||
| Uses | Pharmaceutical | ||
| Storage | Keep in sealed and damp proof place. | ||
| Chemical Specification | Identification | IR | |
| HPLC | |||
| Loss on drying | ≤0.5% | ||
| MP ref. | About 146~152 cdegree | ||
| Optical rotation | Methanl C=1 | ||
| Residue on Ignition | ≤0.5% | ||
| Related substance | Single impurity: ≤0.5% | ||
| Total impurities: ≤1.0% | |||
| Assay(HPLC) | ≥99.0% | ||
| Assay by titration | 99~101% | ||
| Conclusion | Conform to IN-HOUSE | ||
5. Packing :25kg fibre drum
FAQ
Q1: Can you offer free sample?
A1: Yes, we can provide free sample for checking and testing, but you will need to pay the couerier cost.
Q2: Are you a manufacturer or trading company?
A2: We are both manufacturer and trading company.
Q3: Do you have MOQ( Minimum Order Quantity )?
A3: Yes, there is MOQ, but MOQ will be different in each product, we will try our best to satisfy the buyer's order qty.
Q4: What's your standard leadtime/delivery time?
A4: Our standard leadtme is 3-5 working days after receiving payment
Q5: What about the payment term?
A5: We accept T/T, L/C, D/P etc.
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1. Quality
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3. Packing
We can do according to the customers' request.
4. Transport
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5. Service
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