Halobetasol Propionate 66852-54-8

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Molecular Weight:

484.96 Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.






Biological Activity


Halobetasol propionate is thought to act by the induction of
phospholipase A2 inhibitory Proteins, collectively called lipocortins.
It is postulated that these proteins control the biosynthesis of potent
mediators of inflammation such as Prostaglandins and leukotrienes by
inhibiting the release of their common precursor arachidonic acid.


Arachidonic acid is released from membrane phospholipids by
phospholipase A2. The initial interaction, however, is due to the drug
binding to the cytosolic glucocorticoid receptor. After binding the
receptor the newly formed receptor-ligand complex translocates itself
into the cell nucleus, where it binds to many glucocorticoid response
elements (GRE) in the promoter region of the target genes.


The DNA bound
receptor then interacts with basic transcription factors, causing the
increase in expression of specific target genes.

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Product Categories : Metabolism > Phospholipase Inhibitor