Sulfamerazine 127-79-7

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Sulfamerazine

Sulfamerazine Chemical Structure

Molecular Weight: 264.3 Sulfamerazine is a sulfonamide antibacterial.


Biological Activity


Sulfamerazine exhibits biexponential decay in water and triexponential
decay in cyclodextrins solutions. Sulfamerazine shows remarkably upfield
shift in the complexes suggested that the aniline ring deeply
encapsulated in the CD cavity.


Sulfamerazine results in a marked evolution in the shape of the
concentration-time curves in function of age, strongly suggesting a
defective absorption rate in the first weeks after birth in lambs.
Sulfamerazine has a significantly beneficial effect on life span of rats
and apparently increases that of male hamsters, and all rats fed
sulfamerazine attains higher maximum weights than their controls.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	264.3
Formula	C11H12N4O2S
CAS No.	127-79-7

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	53 mg/mL (200.52 mM)
		Water	<1 mg/mL (
		Ethanol	<1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide

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