Rutaecarpine 84-26-4

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Rutaecarpine

Molecular Weight: 287.32 Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.


Biological Activity


Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from
Evodia rutaecarpa and related herbs, which has shown a variety of
intriguing biological properties such as anti-thrombotic, anticancer,
anti-inflammatory and analgesic, anti-obesity and thermoregulatory,
vasorelaxing activity, as well as effects on the cardiovascular and
endocrine systems.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	287.32
Formula	C18H13N3O
CAS No.	84-26-4

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Rutecarpine

Solubility (25°C) *	In vitro	DMSO	24 mg/mL (83.53 mM)
		Water	<1 mg/mL (
		Ethanol	<1 mg/mL (

Chemical Name	Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-

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