Ivermectin 70288-86-7

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Ivermectin

Ivermectin Chemical Structure

Molecular Weight: 875.09 Ivermectin is a broad-spectrum antiparasitic medication.


Biological Activity


Ivermectin is a broad-spectrum antiparasitic medication. Ivermectin is used in the treatment of certain worm infections. It is used to treat river blindness(onchocerciasis)and a certain type of diarrhea(strongyloidiasis). Ivermectin appears to work by paralyzing and then killing the offspring of adult worms. It may also slow down the rate at which adult worms reproduce. This results in fewer worms in the skin, blood, and eyes.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	875.09
Formula	C48H74O14
CAS No.	70288-86-7

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	175 mg/mL (199.97 mM)
		Water	<1 mg/mL (
		Ethanol	28 mg/mL (31.99 mM)

Chemical Name	no

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