Sennoside B

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Molecular Weight:

862.74 Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.


Biological Activity


Sennoside B, a kind of irritant laxative isolated from rhei rhizome,
inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell
proliferation by binding to PDGF-BB and its receptor and down-regulating
the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with
sennoside B inhibits the phosphorylation of pathway components including
Ak strain transforming protein (AKT), signal transducer and activator
of transcription 5 (STAT-5) and extracellular signal-regulated kinase
1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.


LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	862.74
Formula	C42H38O20
CAS No.	128-57-4

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Chemical Name	[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-

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Tech Support & FAQs




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