Aspirin 50-78-2

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Molecular Weight: 180.16 Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Biological ActivityConversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	180.16
Formula	C9H8O4
CAS No.	50-78-2

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Acetylsalicylic acid

Solubility (25°C) *	In vitro	DMSO	36 mg/mL (199.82 mM)
		Water	<1 mg/mL (
		Ethanol	36 mg/mL (199.82 mM)

Chemical Name	2-(acetyloxy)-benzoic acid

Stock Solution (1ml DMSO)	1mM	10mM	20mM	30mM
Mass(mg)	0.18016	1.8016	3.6032	5.4048

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