Lansoprazole 103577-45-3
Product Description
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Molecular Weight:
369.36 Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
Biological Activity
Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.It is used to treat duodenal and gastric ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). Lansoprazole is also used to treat Zollinger-Ellison syndrome (ZES), which is a condition where the stomach produces too much acid.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Contact us if you need more details on 103577-45-3. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Lansoprazole 103577-45-3、103577-45-3 Lansoprazole. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
369.36 Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
Biological Activity
Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.It is used to treat duodenal and gastric ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). Lansoprazole is also used to treat Zollinger-Ellison syndrome (ZES), which is a condition where the stomach produces too much acid.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Contact us if you need more details on 103577-45-3. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Lansoprazole 103577-45-3、103577-45-3 Lansoprazole. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Transmembrane Transporters > Proton Pump Inhibitor
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