Perindopril Erbumine 107133-36-8

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Molecular Weight:

441.6 Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM.

Biological Activity

Perindopril Erbumine displays a higher binding affinity for the
bradykinin binding sites than the angiotensin I binding sites of the
angiotensin-converting enzyme (ACE) with bradykinin/angiotensin I
selectivity ratio of 1.44. Perindopril Erbumine inhibits
the angiotensin- and Aβ42-to-Aβ40-converting activity of mutated ACE
containing two active domains (F-ACE) with IC50 of 0.03-0.1 μM, and
0.01-0.03 μM, respectively.


Perindopril Erbumine (~2 μM)
displays no significant cytotoxicity towards SCC-VII and KB cells, but
can significantly reduce the production of angiotensin II and the
transcription of VEGF in KB cells in a concentration-dependent manner.


Oral administration of Perindopril Erbumine at 2 mg/kg/day has a
significant inhibitory effect on SCC-VII tumor growth, and reduces blood
vessel formation surrounding the tumors in vivo due to the suppression
of VEGF-induced Angiogenesis. Administration of
Perindopril Erbumine at 2 mg/kg/day displays a strong inhibitory effect
of the BNL-HCC tumor growth in rats similar to that of 20 mg/kg/day and
in contrast to the AT1-R antagonist candesartan or losartan which at the
dose of 20 mg/kg/day has no inhibitory effect.


Administration of Perindopril Erbumine at 3 mg/kg/day significantly
inhibits LPS-induced Apoptosis by 6.4% in RAECs in vivo than that of
ramipril by 3.2%. Administration of Perindopril Erbumine
(1 mg/kg/day) significantly suppresses the hippocampal ACE activity, and
prevents cognitive impairment and brain injury in rats with Alzheimer's
disease (AD).

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