Emtricitabine 143491-57-0

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Molecular Weight:

247.25 Emtricitabine (FTC) is a Nucleoside Reverse Transcriptase Inhibitor that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus.

Biological Activity

Emtricitabine moderately reduces hepatocyte proliferation independent of
effects on mtDNA in HepG2 human hepatoma cells. Emtricitabine plus
tenofovir slightly reduced cell proliferation without affecting
mitochondrial parameters. Emtricitabine efficiently
converts to their active metabolites in PBMCs and CEM cells.
Emtricitabine combined with Tenofovir displays additive to synergistic
activity against HIV replication in PBMCs and results in strongly
synergistic anti-HIV activity in MT-2 cells against both wild-type and
mutant virus.


Emtricitabine demonstrates antiviral
activity against laboratory adapted strains of HIV-1 and HIV-2 in
various cell system. Emtricitabine also exhibits antiviral activity in
cell culture against feline and simian immuno-deficiency viruses (SIVs).
Emtricitabine consistently exhibits up to 10-fold greater activity than
lamivudine against all viruses tested in all T-cell lines.


Emtricitabine generally demonstrates greater potency in vitro in human
PBMCs than in MT-4 lines. Emtricitabine also exhibits
anti-HBV activity in vitro (EC50, 0.01–0.04 µM) that is comparable to
the anti-HBV activity of 3TC. Emtricitabine is
approximately fourfold more active than 3TC in assays in the transformed
T-cell line MT-4 infected with HIV-(1IIIB), whereas Zidovudine is more
active than Emtricitabine. Emtricitabine, Lamivudine and Zidovudine are
equally active against a panel of eight primary HIV-1 isolates from
antiretroviral-naive subjects in PBMCs.

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Product Categories : Microbiology > Reverse Transcriptase Inhibitor