Nafamostat Mesylate 82956-11-4

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Molecular Weight:

539.58 Nafamostat mesilate is a synthetic Serine Protease Inhibitor, used as an anticoagulant during hemodialysis.






Biological Activity


Nafamostat mesilate significantly inhibits the release of platelet
beta-thromboglobulin (beta TG) at 60 and 120 min. Nafamostat mesilate
(NM) prevents any significant release of neutrophil elastase; at 120
min, plasma elastase-alpha 1-antitrypsin complex is 0.16 mg/mL in the NM
group and 1.24 mg/mL in the control group. Nafamostat mesilate
completely inhibits formation of complexes of C1 inhibitor with
kallikrein and FXIIa.


Nafamostat mesilate inhibits
several Proteases which may be importantly involved in the
pathophysiology of disseminated intravascular coagulation
(DIC).Nafamostat mesilate inhibits extrinsic pathway activity (TF-F.VIIa
mediated-F.Xa generation) in a concentration dependent manner with IC50
of 0.1 μM. [2] Nafamostat mesilate produces
concentration-dependent inhibition of the initial-phase transient
component of biphasic ASIC3 currents with an IC50 value of approximately
2.5 mM.


Nafamostat mesilate (10 mg/kg) inhibits scratching induced by tryptase
but not by histamine and serotonin. Nafamostat mesilate (1-10 mg/kg)
produces the dose-dependent inhibition of scratching induced by
intradermal compound 48/80 (10 mg/site). Nafamostat mesilate (10 mg/kg)
suppresses tryptase activity in the mouse skin.


Nafamostat mesilate inhibits gemcitabine-induced NF-kappaB activation,
enhances Apoptosis by gemcitabine and suppresses pancreatic tumor
growth. Nafamostat mesilate combined with Gemcitabine improves the body
weight loss of mice induced by Gemicitabine.

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Product Categories : Proteases > Serine Protease Inhibitor