Fisetin 528-48-3

.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}


Molecular Weight:

286.24 Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.


Biological Activity


Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. Fisetin (Fustel) is therefore a caloric restriction mimetic candidate, a compound that has been shown to be able to alleviate ageing effects in certain model organisms such as the yeast S. cerevisiae, the nematode C. elegans and the fruit fly Drosophila melanogaster. Aside from its effects on ageing,various in vitro studies have shown fisetin (Fustel) to exert anti-inflammatory and anti-carcinogenic effects in different lines of culture cells.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	286.24
Formula	C15H10O6
CAS No.	528-48-3

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	57 mg/mL (199.13 mM)
		Water	<1 mg/mL (
		Ethanol	3 mg/mL (10.48 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-

Molarity Calculator
Dilution Calculator
Molecular Weight Calculator

Contact us if you need more details on 528-48-3. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Fisetin 528-48-3、528-48-3 Fisetin. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Epigenetics > Sirtuin Inhibitor