Quercetin 117-39-5

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Molecular Weight:

302.24 Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K Inhibitor with IC50 of 2.4-5.4 μM. Phase 4.


Biological Activity


Quercetin is a type of plant-based chemical, or phytochemical, known as a
flavonol and a plant-derived flavonoid found in fruits, vegetables,
leaves and grains. It also may be used as an ingredient in supplements,
beverages or foods. In several studies, it may have anti-inflammatory
and antioxidant properties, and it is being investigated for a wide
range of potential health benefits. Quercetin (Sophoretin) is a PI3K
inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src
kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and
ERK1/2. Quercetin inhibits TNF-induced LDH% release,
EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial
cells (BPAEC), and BPAEC DNA synthesis and proliferation.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg

Chemical Information

Molecular Weight (MW)	302.24
Formula	C15H10O7
CAS No.	117-39-5

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Sophoretin

Solubility (25°C) *	In vitro	DMSO	61 mg/mL (201.82 mM)
		Water	<1 mg/mL (
		Ethanol	10 mg/mL (33.08 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-

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