Mexiletine HCl 5370-01-4

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Molecular Weight:

215.72 Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

Biological Activity




Mexiletine decreases the effective refractory period (ERP) in
Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude
than the decrease in action potential duration (APD), which results in
an increase in the ERP/APD ratio. It does not significantly affect
resting membrane potential or sinus node automaticity, left ventricular
function, systolic arterial blood pressure, atrioventricular (AV)
conduction velocity, or QRS or QT intervals.


Mexiletine has fast onset and offset kinetics, meaning that they have
little or no effect at slower heart rates, and more effects at faster
heart rates. It shortens the action potential duration, reduces
refractoriness, and decreases Vmax in partially depolarized cells with
fast response action potentials.


Mexiletine either does not change the
action potential duration, or decreases the action potential duration.
Mexiletine is well absorbed (bioavailability 90%) from the
gastrointenstinal tract.

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Product Categories : Transmembrane Transporters > Sodium Channel Inhibitor