BIBR 1532 321674-73-1

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Molecular Weight:

331.36 BIBR 1532 is a potent, selective, non-competitive Telomerase Inhibitor with IC50 of 100 nM.

Biological Activity

BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative
effect in a dose-dependent range with IC50 of 52 μM, and similar results
are also observed in other leukemia cell lines including Nalm-1, HL-60,
and Jurkat.


In addition, BIBR 1532 results in a direct
antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56
μM without affecting the proliferative capacity of normal hematopoietic
progenitor cells. BIBR 1532 (2.5 μM) reduces
colony-forming ability, and induces telomere length shortening as well
as chemotherapeutic sensitization by inhibiting telomerase activity in
MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines.


In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective
cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells
also demonstrates nuclear condensation and formation of apoptotic
bodies morphologically compatible with Apoptosis.


A
recent study shows that combination treatment of BIBR 1532 and
chemotherapeutic agents carboplatin results in a potential synergy for
eliminateing ovarian cancer spheroid-forming cells in ES2, SKOV3, and
TOV112D cell lines.

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Product Categories : DNA Damage > Telomerase Inhibitor