Clinafloxacin 105956-97-6

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Molecular Weight:

365.79 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

Biological Activity

Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic
acid category currently in development for intravenous and oral therapy
of serious infections. Clinafloxacin is a novel
fluoroquinolone with potent broad-spectrum in vitro activity against
gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is
highly active against S.


pneumoniae 7785 (MIC, 0.125 μg/mL), and neither
gyrA nor parC quinolone resistance mutations alone have much effect on
this activity. Clinafloxacin is identified as the most
active fluoroquinolone against S. pneumoniae when compared with
ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin
and is currently being evaluated as an antipneumococcal agent.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

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