Gatifloxacin 112811-59-3

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Molecular Weight:

375.39 Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Biological Activity

Gatifloxacin has somewhat better in vitro activity against M.
tuberculosis than moxifloxacin, and both are much more active than
levofloxacin. Gatifloxacin is against M. tuberculosis ATCC 35801 with
MICs of 0.125 μg/mL. Gatifloxacin possesses potent
inhibitory activities against bacterial type II topoisomerases (50%
inhibitory concentration [IC50] = 13.8 mg/mL for S. aureus topoisomerase
IV; IC50 = 0.109 mg/mL for E. coli DNA gyrase) but the lowest activity
against HeLa cell topoisomerase II (IC50 = 265 mg/mL) among the
quinolones tested.


Gatifloxacin is synergic with the
beta-lactams piperacillin, cefepime and meropenem, and with gentamicin
against some drug-resistant pathogens. Gatifloxacin, an
8-methoxyfluoroquinolone, inhibits a staphylococcal efflux pump.
Gatifloxacin combined with Ciprofloxacinplus shows synergy by the Etest
method for 6 (19%) of the 31 P. aeruginosa isolates using a summation
fractional inhibitory concentration of Gatifloxacin is two-fold less
potent than ciprofloxacin, and the same as or two-fold more potent than
ofloxacin against Enterobacteriaceae.


Gatifloxacin is highly potent
(MIC90s, 0.03-0.06 mg/L) against Haemophilus influenzae, Legionella
spp., Helicobacter pylori and has at least eight-fold better
anti-chlamydial and anti-mycoplasma potency (gatifloxacin MIC90s, 0.13
mg/L).


Gatifloxacin decreases the serum glucose concentration in both normal
and diabetic rats. Gatifloxacin results in an increase in the serum
epinephrine concentration in both normal and diabetic rats.

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Product Categories : DNA Damage > Topoisomerase Inhibitor