Epiandrosterone 481-29-8

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Biological Activity

Epiandrosterone is a natural metabolite of dehydroepiandrosterone
via the 5α-reductaseenzyme. Epiandrosterone is formed in peripheral
tissues, from which it is released into the circulation and is
ultimately excreted in the urine.


Epiandrosterone is only a weak
androgen, but it is widely recognized to inhibit the pentose
phosphate pathway (PPP) and to decrease intracellular NADPH levels. Epiandrosterone attenuates NO-evoked relaxation of pulmonary artery ,
although it inhibits angiotensin II- and hypoxia-induced
vasoconstriction in isolated lungs and relaxes isolated pulmonary
arteries pre-constricted with KCl.

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Product Categories : Endocrinology & Hormones > Androgen Receptor Inhibitor