PD128907 HCl 112960-16-4

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Molecular Weight: 285.77 PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist,
with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2
receptor. When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) PD 128907 is used for studying the role of these receptors in the
brain, in roles such as inhibitory autoreceptors that act to limit
further dopamine release.

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Product Categories : Neuronal Signaling > Dopamine Receptor Inhibitor