Atazanavir Sulfate 229975-97-7

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Molecular Weight:

802.93 Atazanavir is a HIV Protease Inhibitor with Ki of 2.66 nM.






Biological Activity


Atazanavir inhibits the proteolytic cleavage of the viral gag precursor
p55 polyprotein with IC50 of ~47 nM in virus-infected H9 cells.
Atazanavir exhibits potent antiviral activity with EC50 of 3.89 nM in
RF/MT-2 strains. Atazanavir is shown to be an inhibitor
of bilirubin glucuronidation with IC50 of 2.4 μM. Atazanavir inhibits
recombinant UGT1A1 with Ki of 1.9 μM.


Atazanavir inhibits
cell growth in U251, T98G, and LN229 glioblastoma cell lines, with
strikingly increased GRP78 and CHOP protein levels. Atazanavir causes a
prominent increase of polyubiquitinated Proteins of various different
sizes in U251 glioblastoma cells.


Atazanavir also
inhibits human 20S proteasome with IC50 of 26 μM. Atazanavir (30 μM)
changes the magnitudes of ER stress and UPR gene expression in HepG2
cells. Atazanavir (30 mM) causes a 2.5-fold increase in
immunoreactive P-gp expression with decreased intracellular Rh123 in
LS180V cells.

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Product Categories : Proteases > HIV Protease Inhibitor