Bismuth Subcitrate Potassium 880149-29-1

.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}


Molecular Weight: 782.67 Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.


Biological Activity


Colloidal Bismuth Subcitrate is crystallized in dilute HCl at pH 3, and
unique assembly of three basic bismuth citrate dimeric units
([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D
polymer, the solubility of Colloidal Bismuth Subcitrate in water is
found to be dramatically affected by pH, from >70 mg/mL at pH 7 to
only about 1 mg/mL at pH 3. Bismuth Subcitrate is effective against the
12 C. pyloridis strains with MIC50 of 8 μg/mL. Bismuth Subcitrate
combined with oxolinic acid exhibits synergistic activity against the 12
C. pyloridis strains.


Colloidal bismuth subcitrate (5 mg/mL)
significantly increases the frequencies of sister-chromatid exchange
(SCE) and micronucleus rate in peripheral lymphocytes compared with
controls in human whole blood cultures. Bismuth Subcitrate (100μM)
inhibits Helicobacter pyloriF1-ATPase activity, and inhibition is
prevented and reversed by the mercaptan glutathione, indicating that
Bismuth Subcitrate interfere with sulfhydryl groups of the enzyme.
Colloidal Bismuth Subcitrate (150 mg/mL) inhibits the lipolytic activity
of C. pylori filtrate, causing a 21% reduction in lipase activity and a
60% reduction in the activity of phospholipase A.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	782.67
Formula	C12H10BiK5O14+2
CAS No.	880149-29-1

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	<1 mg/mL (
		Water	100 mg/mL (127.76 mM)
		Ethanol	<1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3+) potassium salt (2:1:5)

Molarity Calculator
Dilution Calculator
Molecular Weight Calculator

Contact us if you need more details on Bismuth Subcitrate Potassium. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 880149-29-1、880149-29-1 Bismuth Subcitrate Potassium. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Others > Other