Stigmasterol 83-48-7

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Molecular Weight: 412.69 Stigmasterol is an unsaturated plant sterol, which may be useful in prevention of certain cancers.


Biological Activity


Stigmasterol is an unsaturated plant sterol occurring in the plant fats
or oils of soybean, calabar bean, and rape seed, and in a number of
medicinal herbs, including the Chinese herbs Ophiopogon japonicus (Mai
men dong) and American Ginseng. Stigmasterol(Stigmasterin) is used as a precursor in the manufacture of synthetic progesterone,
a valuable human hormone that plays an important physiological role in
the regulatory and tissue rebuilding mechanisms related to estrogen
effects, as well as acting as an intermediate in the biosynthesis of
androgens, estrogens, and corticoids. It is also used as the precursor
of vitamin D3. Research has indicated that stigmasterol may
be useful in prevention of certain cancers, including ovarian, prostate,
breast, and colon cancers.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	412.69
Formula	C29H48O
CAS No.	83-48-7

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Stigmasterin

Chemical Name	(24S)-24-Ethylcholesta-5,22-dien-3β-ol

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