Acarbose 56180-94-0
Product Description
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Acarbose
Acarbose Chemical Structure
Molecular Weight: 645.6 Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.
Biological Activity
Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is an inhibitor of alpha glucosidase, an enteric enzyme that releases glucose from larger carbohydrates.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
Contact us if you need more details on Acarbose. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 56180-94-0、56180-94-0 Acarbose. If these products fail to match your need, please contact us and we would like to provide relevant information.
Acarbose
Acarbose Chemical Structure
Molecular Weight: 645.6 Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.
Biological Activity
Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is an inhibitor of alpha glucosidase, an enteric enzyme that releases glucose from larger carbohydrates.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
| Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
| Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
| Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
| rat Km(6) |
Chemical Information
| Molecular Weight (MW) | 645.6 |
|---|---|
| Formula | C25H43NO18 |
| CAS No. | 56180-94-0 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in solvent (DMSO, water, etc.) | |
| Synonyms | BAY g 5421 |
| Solubility (25°C) * | In vitro | DMSO | 129 mg/mL (199.81 mM) |
|---|---|---|---|
| Water | 129 mg/mL (199.81 mM) | ||
| Ethanol | 8 mg/mL (12.39 mM) | ||
| Chemical Name | (2R,3R,4R,5S,6R)-5-((2R,3R,4R,5S,6R)-5- |
|---|
Contact us if you need more details on Acarbose. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 56180-94-0、56180-94-0 Acarbose. If these products fail to match your need, please contact us and we would like to provide relevant information.
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