Dropropizine 17692-31-8

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Molecular Weight: 236.31 Dropropizine is a racemic non-opiate antitussive agent, it is used as a cough suppressant.


Biological Activity


Dropropizine shows neither mutagenic nor clastogenic effects in Chinese
hamster V79 and human EUE cells, while Lithium carbonicum manifestes a
weak and mazindol a medium genotoxic response which is in both cases
reduce in the presence of microsomal fraction S9.


Dropropizine exhibits antitussive activity in cats noticeably lower than Pinacidil and Codeine. Dropropizine (100 mg/kg, b.w., intraperitoneally) has similar antitussive activity as that of EEPF (200 mg/kg, b.w., orally).
Dropropizine exhibits antitussive activity of 28.3% in mechanically
induced cough in nonanaesthetized cats, comparable to prenoxdiazine
(24.7%). Dropropizine (dropro–dose 100 mg/kg b.w.) exhibits comparable
cough-suppressing effect of mucilage from S. althaeae. Dropropizine
(dropro–dose 100 mg/kg b.w.) exhibits antitussive activity less than E.
officinalis on the mechanically induced cough reflex under experimental
conditions.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	236.31
Formula	C13H20N2O2
CAS No.	17692-31-8

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	47 mg/mL (198.89 mM)
		Water	11 mg/mL (46.54 mM)
		Ethanol	47 mg/mL (198.89 mM)

Chemical Name	1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-

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