TTNPB (Arotinoid Acid) 71441-28-6

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Molecular Weight:

348.48 TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.

Biological Activity

TTNPB binds to nuclear retinoic acid receptors with high affinity, inhibits binding of [3H]tRA with IC50 of 3.8 nM, 4.0 nM, and 4.5 nM for mRARα, β, and γ, respectively. TTNPB increases transcriptional activation of Mouse RARs in JEG-3 cells
after 72 h using conditioned media with EC50 of 2.0 nM, 1.1 nM and 0.8
nM for mRARα, β, and γ, respectively.


TTNPB inhibits the
growth of normal human mammary epithelial cells (HMECs) and estrogen
receptor-positive (ER-positive) breast cancer cells by inducing G1 cell
cycle blockade. TTNPB causes a concentration-dependent decrease in ES-D3 cell differentiation.


TTNPB (0.25 mg/kg) causes growth inhibition in both MXT-HS and MXT-HI models by inducing cell Apoptosis.

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Product Categories : Metabolism > Retinoid Receptor Inhibitor